ABSTRACT
BACKGROUND AND OBJECTIVES: Hearing outcomes and prognostic factors of idiopathic sudden sensorineural hearing loss (SSNHL) were investigated in patients who underwent combined intratympanic and systemic steroid therapy. SUBJECTS AND METHOD: This study was performed by retrospective chart review. Clinical outcomes and prognostic factors were evaluated in 147 patients who received intratympanic steroid plus systemic steroid therapy. RESULTS: Complete hearing recovery was achieved in 36.7% (n=54) of the patients, partial recovery in 12.9% (n=19), slight recovery in 12.3% (n=18), and total recovery in 61.9% (n=91). Age was identified as an independent, negative prognostic factor for hearing recovery. The recovery rates of the down sloping and profound types were poorer than those of the up sloping type as determined by audiography. CONCLUSION: The results of this study suggest that the combined treatment of intratympanic and systemic steroids for idiopathic SSNHL results in high hearing recovery rates, and that the down-sloping and profound types of audiogram patterns and age are negative prognostic factors.
Subject(s)
Humans , Ear, Middle , Hearing Loss , Hearing Loss, Sensorineural , Hearing , Methods , Prognosis , Retrospective Studies , SteroidsABSTRACT
BACKGROUND AND OBJECTIVES: Laryngeal electromyography (LEMG) is valuable for the prognosis of vocal fold paralysis (VFP). However, there is a lack of reliable data to apply it to clinical practice. The aim of this study is to evaluate the reliability of interference pattern of LEMG in order to predict the prognosis of VFP by comparing interference pattern and vocal cord mobility. SUBJECTS AND METHOD: A retrospective chart review was performed for patients who underwent LEMG from January 2012 to October 2015. Gender and age of patients, cause and treatment of VFP, vocal cord mobility, and result of LEMG were analyzed. The interference pattern of LEMG was used as a predictive marker of prognosis, which is compared with vocal cord mobility during the last follow-up. RESULTS: Fifteen patients were enrolled in this study. Among them, five patients were predicted by LEMG evaluation to have good prognosis, and 10 patients were predicted to have poor prognosis. All of the five patients with good prognosis showed improvement in vocal cord mobility, while seven out of 10 patients predicted with bad prognosis showed vocal fold fixation at the last follow-up. The reliability of prognostic prediction through interference pattern was 80%. CONCLUSION: Interference pattern of LEMG is reliable data to predict the prognosis of VFP, especially it showed perfect consistency for good prognosis.
Subject(s)
Humans , Electromyography , Follow-Up Studies , Methods , Paralysis , Prognosis , Retrospective Studies , Vocal CordsABSTRACT
BACKGROUND AND OBJECTIVES: This study evaluated the efficacy of combination therapy of proton pump inhibitor (PPI) and steroid inhaler (SI), with or without botulinum toxin injection (BTX) for contact granuloma. SUBJECTS AND METHODS: Fourteen contact granuloma patients were enrolled in this study. Combination therapy of PPI and SI were used for the first line treatment. When combination therapy was not effective, BTX was performed as the second method. Treatment results were recorded as responsible or non-responsible. Farwell grade, size, history of voice abuse, gender, and reflux finding score (RFS) were compared between responsible group and non-responsible group. RESULTS: Initial response rate was 28.6% after treatment of PPI and SI. BTX was performed on three un-responsible patients. After BTX injection, three patients had complete remission of granuloma. Final response rate was 50.0%. Un-responsible group had significantly higher RFS than responsible group. CONCLUSION: The efficacy of PPI and SI was limited for contact granuloma in this study. Botulium toxin injection was recommended in early phase when PPI and SI did not effective for contact granuloma. Prospective studies evaluating the effects of PPI and SI are warranted.